Increased Levels of ɛ and γ Isoforms of 14-3-3 Proteins in Cerebrospinal Fluid in Patients with Creutzfeldt-Jakob Disease
نویسندگان
چکیده
منابع مشابه
Increased Levels of ε and g Isoforms of 14-3-3 Proteins in Cerebrospinal Fluid in Patients with Creutzfeldt-Jakob Disease
HIDEHIRO TAKAHASHI,* TOSHINARI IWATA, YOSHINORI KITAGAWA, REISUKE H. TAKAHASHI, YUKO SATO, HIDEKI WAKABAYASHI, MIWA TAKASHIMA, HIROSHI KIDO, KAZUO NAGASHIMA, KIMBRA KENNEY, CLARENCE J. GIBBS, JR., AND TAKESHI KURATA Department of Pathology, National Institute of Infectious Diseases, Tokyo, Division of Enzyme Chemistry, Institute of Enzyme Research, University of Tokushima, Tokushima, Laboratory...
متن کاملHashimoto’s Encephalopathy with Positive 14-3-3 Protein in the Cerebrospinal Fluid and Atypical Course Mimicking Creutzfeldt-Jakob Disease
Hashimoto’s encephalopathy (HE) is a rare neurological disorder with a heterogeneous group of neurological symptoms.1 Sporadic Creutzfeldt-Jakob disease (CJD) is the most common human prion disease and usually manifests as a rapidly progressive dementia, with ataxia and myoclonus leading to death in less than 1 year.2 CJD shares common clinical features with HE, and dementia, myoclonus, extrapy...
متن کاملA comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
OBJECTIVE To compare the respective efficiency of CSF tau (quantitative) and CSF 14-3-3 protein (qualitative) in the diagnosis of prion disease. METHODS We made measurements on 420 live subjects, who subsequently underwent a postmortem neuropathology examination, including protein chemistry, immunohistochemistry, and histology. We performed tau by ELISA. We detected 14-3-3 protein by Western ...
متن کاملUse of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease.
OBJECTIVES The detection of the protein 14-3-3 in the CSF has been shown to be a reliable and sensitive marker for sporadic Creutzfeldt-Jakob disease (CJD). Other brain-specific proteins such as neuron specific enolase (NSE), S-100b, and tau protein have also been reported to be increased in the CSF of patients with sporadic CJD. In 1996 a variant of CJD (vCJD) was described which is likely to ...
متن کاملUse of 14-3-3 in the diagnosis of Creutzfeldt-Jakob disease.
The transmissible spongiform encephalopathies include human diseases such as Creutzfeldt-Jakob disease (CJD) and kuru as well as animal diseases such as scrapie and bovine spongiform encephalopathy (BSE). The emergence of variant CJD, which is causally related to BSE, has generated much interest in the development of rapid and sensitive diagnostic tests for the pre-mortem diagnosis of CJD. In 1...
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ژورنال
عنوان ژورنال: Clinical Diagnostic Laboratory Immunology
سال: 1999
ISSN: 1071-412X,1098-6588
DOI: 10.1128/cdli.6.6.983-985.1999